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Smitha Antony Selected Research

6- (3- (2- hydroxyethyl)amino- 1- propyl)- 5,6- dihydro- 2,3- dimethoxy- 8,9- methylenedioxy- 5,11- dioxo- 11H- indeno(1,2- )isoquinoline

2/2005Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison.
11/2003Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.

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Smitha Antony Research Topics

Disease

36Neoplasms (Cancer)
01/2020 - 07/2003
7Inflammation (Inflammations)
11/2019 - 02/2013
6Pancreatic Neoplasms (Pancreatic Cancer)
11/2019 - 04/2011
5Colonic Neoplasms (Colon Cancer)
01/2020 - 01/2008
3Breast Neoplasms (Breast Cancer)
01/2020 - 06/2005
3Adenocarcinoma
01/2020 - 10/2016
3Genomic Instability
10/2017 - 04/2014
3Poisoning
07/2011 - 02/2005
2Melanoma (Melanoma, Malignant)
12/2017 - 12/2013
2Hypoxia (Hypoxemia)
12/2017 - 08/2014
2Chronic Pancreatitis
06/2015 - 04/2013
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
06/2015 - 04/2013
2Carcinogenesis
06/2014 - 04/2013
1Colorectal Neoplasms (Colorectal Cancer)
01/2020
1Adenomatous Polyps
01/2020
1Ovarian Neoplasms (Ovarian Cancer)
10/2017
1Gastrointestinal Neoplasms (Gastrointestinal Cancer)
10/2016
1Carcinoma in Situ
10/2016
1Necrosis
06/2015
1Neoplasm Metastasis (Metastasis)
04/2014
1Thyroid Neoplasms (Thyroid Cancer)
04/2013
1Lymphoma (Lymphomas)
04/2013
1Brain Neoplasms (Brain Tumor)
04/2013
1Pancreatitis
02/2013
1Ataxia Telangiectasia (Louis Bar Syndrome)
12/2009

Drug/Important Bio-Agent (IBA)

12Proteins (Proteins, Gene)FDA Link
01/2020 - 02/2005
10CytokinesIBA
01/2020 - 04/2011
10Reactive Oxygen Species (Oxygen Radicals)IBA
01/2020 - 04/2011
8NADPH Oxidases (NAD(P)H oxidase)IBA
01/2020 - 02/2013
8CamptothecinIBA
03/2010 - 12/2003
7Dual OxidasesIBA
11/2019 - 04/2011
5EnzymesIBA
01/2020 - 11/2004
5Pharmaceutical PreparationsIBA
03/2010 - 11/2003
4Monoclonal AntibodiesIBA
01/2020 - 04/2013
4Messenger RNA (mRNA)IBA
01/2020 - 07/2006
4DNA (Deoxyribonucleic Acid)IBA
04/2014 - 06/2005
42- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
03/2010 - 11/2003
4Type I DNA Topoisomerases (Topoisomerase I)IBA
05/2007 - 07/2003
4Topoisomerase I InhibitorsIBA
07/2005 - 12/2003
3NADPH Oxidase 1IBA
01/2020 - 06/2017
3Protein Isoforms (Isoforms)IBA
01/2020 - 06/2014
3Interleukin-4 (Interleukin 4)IBA
11/2019 - 05/2012
3Oxygen (Dioxygen)IBA
12/2017 - 04/2011
3Oxidants (Oxidizing Agents)IBA
06/2017 - 04/2013
3Interleukin-13IBA
06/2017 - 05/2012
2Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
11/2019 - 10/2016
2NADPH Oxidase 5IBA
12/2017 - 12/2013
24,6-dinitro-o-cresol (DNOC)IBA
12/2017 - 05/2012
2Small Interfering RNA (siRNA)IBA
12/2017 - 10/2016
2Oxidoreductases (Dehydrogenase)IBA
12/2017 - 05/2012
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2017 - 10/2016
2diphenyleneiodoniumIBA
10/2016 - 05/2012
2AntibodiesIBA
06/2014 - 04/2013
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
04/2014 - 04/2011
2tyrosyl-DNA phosphodiesteraseIBA
03/2010 - 01/2010
2Biomarkers (Surrogate Marker)IBA
07/2009 - 06/2005
2TrabectedinIBA
10/2008 - 01/2008
2LactonesIBA
09/2006 - 11/2003
2Antineoplastic Agents (Antineoplastics)IBA
06/2005 - 07/2003
2Biological ProductsIBA
06/2005 - 11/2004
26- (3- (2- hydroxyethyl)amino- 1- propyl)- 5,6- dihydro- 2,3- dimethoxy- 8,9- methylenedioxy- 5,11- dioxo- 11H- indeno(1,2- )isoquinolineIBA
02/2005 - 11/2003
1Superoxides (Superoxide)IBA
01/2020
1ParaffinIBA
01/2020
1Surface Antigens (Surface Antigen)IBA
01/2020
1Formaldehyde (Formol)FDA Link
01/2020
1Interleukin-17 (Interleukin 17)IBA
11/2019
1Phosphoprotein Phosphatases (Phosphatases, Protein)IBA
12/2017
1Bromodeoxyuridine (BrdU)IBA
12/2017
1human NOX4 proteinIBA
10/2017
1NADPH Oxidase 4IBA
10/2017
1Membrane Proteins (Integral Membrane Proteins)IBA
10/2017
1Interleukin-4 Receptors (Interleukin 4 Receptor)IBA
06/2017
1Sulfhydryl Compounds (Thiols)IBA
10/2016
1Acetylcysteine (Siran)FDA LinkGeneric
10/2016
1Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
10/2016
1CatalaseIBA
10/2016
1InterferonsIBA
06/2015
1InterleukinsIBA
06/2015
1BuffersIBA
08/2014
1ImmunosorbentsIBA
08/2014
1NitrogenIBA
08/2014
1Aligeron (AS 2)IBA
08/2014
1alpha-hydroxyglutarateIBA
08/2014
1Proteasome InhibitorsIBA
08/2014
1Prolyl-Hydroxylase InhibitorsIBA
08/2014
1Reactive Nitrogen SpeciesIBA
04/2014
1Amino AcidsFDA Link
04/2013
1LipopolysaccharidesIBA
02/2013
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
05/2012
1Interleukin-6 (Interleukin 6)IBA
05/2012
1FlavoproteinsIBA
05/2012
1iodonium thiopheneIBA
05/2012
1Interleukin-22 (IL-22)IBA
05/2012
1SugarsIBA
07/2011
1Interferon-gamma (Interferon, gamma)IBA
04/2011
1DNA-Activated Protein KinaseIBA
12/2009
1Protein Kinases (Protein Kinase)IBA
12/2009
1Topotecan (Hycamtin)FDA LinkGeneric
11/2009
1Irinotecan (Camptosar)FDA LinkGeneric
11/2009

Therapy/Procedure

2Therapeutics
11/2009 - 06/2005